The Hidden Cost of Foodborne Illness in the United States

Written by: Cindy Ignis

May 8, 2025

Every year, millions of Americans enjoy a diverse and abundant food supply, but beneath the surface lies a persistent public health challenge: foodborne illness. Often referred to as food poisoning, these illnesses strike with alarming frequency, causing significant health and economic impacts. Using the latest available data, this article explores the scope of foodborne illness in the United States, its primary causes, and what can be done to reduce its burden.

A Staggering Scale of Illness

According to the Centers for Disease Control and Prevention (CDC), approximately 48 million people in the United States fall ill from foodborne diseases each year. That’s roughly 1 in 6 Americans, making it a widespread issue that touches nearly every community. Of these cases, 128,000 lead to hospitalizations, and tragically, 3,000 result in deaths annually. These numbers highlight the severity of the problem, as even a single outbreak can affect thousands and strain healthcare systems.

The CDC further estimates that 9.9 million of these illnesses are caused by seven major pathogens, including norovirus, Salmonella, Campylobacter, Clostridium perfringens, Listeria, Shiga toxin-producing Escherichia coli (STEC), and Toxoplasma gondii. The remaining 38.4 million cases are attributed to unspecified agents, underscoring the complexity of tracking and identifying all sources of contamination.

The Leading Culprits

Among the known pathogens, norovirus stands out as the leading cause of foodborne illness, responsible for an estimated 5.5 million cases annually. It’s also the top contributor to hospitalizations, with 22,400 cases requiring medical attention. Norovirus spreads easily through contaminated food, water, or surfaces, often in settings like restaurants, where 48% of outbreaks between 2017 and 2019 were linked to poor hygiene or cross-contamination.

Salmonella is another major player, causing around 1 million illnesses each year and leading to 238 deaths, making it the top pathogen for fatal outcomes. Poultry, eggs, and meat are frequent sources, with over 23% of cases tied to chicken and turkey. In 2021, chicken and fruits were the most common food categories linked to Salmonella outbreaks. The rate of Salmonella infections has remained stable at about 18 per 100,000 people, but its persistence signals ongoing challenges in food production and handling.

Other pathogens like Campylobacter (0.8 million cases), Clostridium perfringens (1 million cases), and STEC also contribute significantly. Listeria, while less common, is particularly dangerous, especially for pregnant women and immunocompromised individuals, often leading to severe outcomes like miscarriages or death.

Economic and Social Toll

Beyond the human toll, foodborne illnesses carry a hefty economic price tag. A study by the USDA’s Economic Research Service estimates the annual cost at $75 billion (in 2023 dollars), factoring in medical expenses, lost productivity, and premature deaths. This figure doesn’t account for the emotional and social impact on families or the reputational damage to businesses implicated in outbreaks.

High-profile outbreaks, like the 2009 Salmonella outbreak tied to the Peanut Corporation of America, which sickened 714 people and caused nine deaths, or the 2011 Listeria outbreak from Jensen Farms cantaloupes, which led to 33 deaths, illustrate how quickly contamination can spiral. These incidents often trigger massive recalls—over 3,600 peanut butter products in the PCA case and 300,000 cantaloupes from Jensen Farms—disrupting supply chains and eroding consumer trust.

Vulnerable Populations

While anyone can contract a foodborne illness, certain groups face higher risks. Pregnant women, children under 5, older adults, and those with weakened immune systems (e.g., from diabetes, cancer, or HIV/AIDS) are more likely to experience severe symptoms or complications. For example, foodborne illness during pregnancy can lead to miscarriage, stillbirth, or premature delivery. Young children lack fully developed immune systems, and older adults have slower immune responses, making them more susceptible to pathogens like Listeria or Salmonella.

Challenges in Detection and Prevention

One of the biggest hurdles in addressing foodborne illness is underreporting. The CDC relies on voluntary reporting from state and local health departments, but resource constraints often limit investigations. As a result, many cases go unreported, and the true burden may be even higher than estimated.

Federal agencies like the CDC, FDA, and USDA’s Food Safety and Inspection Service (FSIS) have set goals to reduce foodborne illness, but progress has been uneven. For instance, FSIS aimed to reduce Salmonella in poultry by 4%, but the proportion of contaminated samples actually increased by 22% in one year. A lack of a unified national food safety strategy complicates efforts, as 15 federal agencies administer at least 30 laws governing food safety, often with overlapping or unclear responsibilities.

Steps Toward a Safer Food Supply

Despite these challenges, foodborne illnesses are largely preventable. Effective interventions include:

  • Improved Food Handling: Proper cooking, storage, and hygiene practices—like washing hands, surfaces, and produce—can significantly reduce risks. Consumers should avoid raw or undercooked meat, eggs, and unpasteurized dairy, which are common sources of contamination.
  • Stronger Regulations: Outbreaks have historically driven policy changes, like the stricter meat handling rules following the 1993 Jack in the Box E. coli outbreak, which killed four people. Continued investment in inspections and enforcement is critical.
  • Public Awareness: Educating consumers about food recalls and safe preparation methods can empower individuals to protect themselves. The FDA’s Food Information Line (1-888-SAFEFOOD) and CDC’s outbreak alerts provide valuable resources.
  • Industry Accountability: High-profile convictions, like the 28-year sentence for the Peanut Corporation of America’s CEO, signal growing legal consequences for negligence. Companies must prioritize safety to avoid both human and financial losses.

Looking Ahead

Foodborne illness remains a formidable challenge, but it’s not insurmountable. The CDC’s upcoming 2025 report on seven major pathogens will provide updated insights, building on 2019 estimates. Meanwhile, the World Health Organization’s global burden estimates, due in 2025, will offer a broader perspective, emphasizing the need for coordinated action.

By strengthening food safety systems, enhancing surveillance, and fostering collaboration between government, industry, and consumers, the United States can reduce the staggering toll of foodborne illness. Until then, staying informed and vigilant remains our best defense against this hidden threat.

Sources:

  • Centers for Disease Control and Prevention (CDC)
  • U.S. Government Accountability Office (GAO)
  • U.S. Food and Drug Administration (FDA)
  • USDA Economic Research Service
  • World Health Organization (WHO)

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